Chen C F, Kuo C H
Department of Physiology, College of Medicine, National Taiwan University, Taipei, R.O.C.
J Formos Med Assoc. 1992 Aug;91(8):743-6.
Ingestion of raw bile from some grass carp fish has been reported to be associated with impairment of renal function in some Chinese people. 5 alpha-cyprinol, the main bile alcohol in these fish, has been suggested as the toxic compound causing electrolyte imbalance. In this study, we attempted to determine whether oral administration of pure bile acids also affects the electrolyte balance in rats. Twenty-four female Long-Evans rats weighing 200-250 g were used. Conscious cannulated animals were prepared and studied with gastric intubation of 15%, 4.8 mL/kg of sodium cholate (SC), sodium deoxycholate (SD), and water; there were three groups of eight rats in each. A drastic drop in blood pressure, elevation of the ST segment of the EKG, increases in plasma potassium, hydrogen, blood urea nitrogen, and oxygen partial pressure were found. All rats treated with bile acids died within 24 hours. Six SD rats and three SC rats died within eight hours after oral administration of bile acid. It is concluded that the effects of feeding rats bile acids are very similar to the toxic action seen after ingestion of grass carp bile.
据报道，一些中国人摄入某些草鱼的生胆汁与肾功能损害有关。5α-鲤醇是这些鱼中的主要胆汁醇，被认为是导致电解质失衡的有毒化合物。在本研究中，我们试图确定口服纯胆汁酸是否也会影响大鼠的电解质平衡。使用了24只体重200-250克的雌性Long-Evans大鼠。制备清醒插管动物，并通过胃内插管给予15%、4.8 mL/kg的胆酸钠（SC）、脱氧胆酸钠（SD）和水；每组有八只大鼠，共三组。发现血压急剧下降、心电图ST段抬高、血浆钾、氢离子、血尿素氮和氧分压升高。所有用胆汁酸处理的大鼠在24小时内死亡。六只SD大鼠和三只SC大鼠在口服胆汁酸后八小时内死亡。结论是，给大鼠喂食胆汁酸的效果与摄入草鱼胆汁后所见的毒性作用非常相似。
