Nayfield S G, Ganz P A, Moinpour C M, Cella D F, Hailey B J
Community Oncology and Rehabilitation Branch, National Cancer Institute, Bethesda, MD 20892.
Qual Life Res. 1992 Jun;1(3):203-10. doi: 10.1007/BF00635619.
To promote the inclusion of quality of life (QOL) end-points in clinical research on cancer, the National Cancer Institute (USA) sponsored a workshop on QOL assessment in cancer clinical trials in July, 1990. Experts in clinical trials and QOL research formed four working groups to identify current areas of cancer treatment in which QOL end-points are most important; to discuss methodologic problems in QOL assessment; to address common problems in implementing clinical studies with QOL end-points; and to consider statistical issues in design, implementation, and data analysis. Recommendations made by the working groups are summarized in this paper.
为推动将生活质量（QOL）终点纳入癌症临床研究，美国国立癌症研究所于1990年7月主办了一次关于癌症临床试验中QOL评估的研讨会。临床试验和QOL研究领域的专家组成了四个工作组，以确定目前癌症治疗中QOL终点最为重要的领域；讨论QOL评估中的方法学问题；解决在开展有QOL终点的临床研究时出现的常见问题；并考虑设计、实施及数据分析中的统计学问题。本文总结了各工作组提出的建议。
