Muscat R, Papp M, Willner P
Department of Psychology, City of London Polytechnic, UK.
Psychopharmacology (Berl). 1992;109(4):433-8. doi: 10.1007/BF02247719.
Chronic exposure to mild unpredictable stress has previously been found to depress the consumption of palatable sweet solutions. In the present study this effect was reversed by chronic (9 weeks) treatment with the atypical antidepressants, fluoxetine and maprotiline (5 mg/kg/day); the non-antidepressant chlordiazepoxide was ineffective. Stressed animals were also subsensitive to food reward in the place conditioning procedure; however, fluoxetine and maprotiline treated animals showed normal place preference conditioning. Acute pretreatment with raclopride (100 micrograms/kg) selectively reversed the recovery of sucrose drinking in antidepressant-treated stressed animals. These results extend previous reports of the efficacy of tricyclic antidepressants in this paradigm, and support the hypothesis of a dopaminergic mechanism of antidepressant action.
先前已发现，长期暴露于轻度不可预测应激会降低可口甜味溶液的摄入量。在本研究中，非典型抗抑郁药氟西汀和马普替林（5毫克/千克/天）进行9周的长期治疗可逆转这种效应；非抗抑郁药氯氮卓则无效。在位置条件反射实验中，应激动物对食物奖励也不敏感；然而，经氟西汀和马普替林治疗的动物表现出正常的位置偏好条件反射。用雷氯必利（100微克/千克）进行急性预处理可选择性逆转抗抑郁药治疗的应激动物蔗糖摄入量的恢复。这些结果扩展了先前关于三环类抗抑郁药在此范例中疗效的报道，并支持了抗抑郁作用的多巴胺能机制假说。
