Libondi T, Costagliola C, Della Corte M, Facchiano F, Menzione M, Savastano S, Simonelli F, Rinaldi E, Auricchio G
Eye Clinic First Medical School, Naples, Italy.
Metab Pediatr Syst Ophthalmol (1985). 1991;14(2):31-6.
Since many years experimental evidences have suggested an association between nutrition and lens opacities. A dietary deficiency of antioxidants and reactive oxygen scavengers may be involved in the pathogenesis of the "idiopathic" human senile cataract, as it has been demonstrated in some experimental cataracts. We tested the levels of ascorbic acid (vit. C), alpha-tocopherol (vit. E), reduced glutathione (GSH) and malondialdehyde (MDA) in the plasma or in the red blood cells (RBC) of 42 patients who were affected by surgically significant cataract and of 40 age-matched controls. Plasma vit. C mean level was 4.46 gamma/ml in cataracts and 4.62 gamma/ml in controls, while vit. E level was 7.70 and 7.09 gamma/ml respectively. RBC GSH was found to be 342 gamma/ml in cataracts and 346 in controls, while the MDA content was 4.06 picoMol/ml and 4.08 picoMol/ml respectively. The level of each tested nutrient or metabolite was not found to be statistically different between cataractous patients and controls, nor any significant trend was found to be present when the nutrients and metabolites were correlated to each other. Our results do not support the hypothesis of a nutritional deficiency in human senile cataracts. However, a defect in the antioxidative metabolism pathways could be present either systemically or at lens level.
多年来，实验证据表明营养与晶状体混浊之间存在关联。抗氧化剂和活性氧清除剂的饮食缺乏可能参与了“特发性”人类老年性白内障的发病机制，正如在一些实验性白内障中所证明的那样。我们检测了42例患有具有手术指征白内障的患者以及40例年龄匹配的对照组的血浆或红细胞（RBC）中抗坏血酸（维生素C）、α-生育酚（维生素E）、还原型谷胱甘肽（GSH）和丙二醛（MDA）的水平。白内障患者血浆维生素C平均水平为4.46微克/毫升，对照组为4.62微克/毫升，而维生素E水平分别为7.70和7.09微克/毫升。白内障患者红细胞GSH为342微克/毫升，对照组为346微克/毫升，而MDA含量分别为4.06皮摩尔/毫升和4.08皮摩尔/毫升。未发现白内障患者与对照组之间每种检测的营养素或代谢物水平存在统计学差异，并且当营养素和代谢物相互关联时，也未发现任何显著趋势。我们的结果不支持人类老年性白内障存在营养缺乏的假设。然而，抗氧化代谢途径可能在全身或晶状体水平存在缺陷。
