Brawer M K
Department of Urology, University of Washington, Seattle 98195.
Hum Pathol. 1992 Mar;23(3):242-8. doi: 10.1016/0046-8177(92)90104-b.
Putative premalignant changes in the prostate have been recognized for a number of years. A variety of synonyms have been given to the most commonly described lesion, one characterized by proliferation and dysplasia of the normal two cell layers lining prostatic acini and ductules. Currently, "prostatic intraepithelial neoplasia" (PIN) is the term most commonly used to describe this entity. In this review, the requirements for a premalignant lesion, the reason why PIN fulfills the majority of these requirements, and a detailed description of the morphologic and phenotypic similarities between PIN and carcinoma will be outlined. Finally, the clinical significance of PIN will be reviewed.
前列腺潜在的癌前病变已被认识多年。对于最常描述的病变有多种同义词，该病变的特征是前列腺腺泡和小管内衬的正常两层细胞增殖和发育异常。目前，“前列腺上皮内瘤变”（PIN）是最常用于描述这一实体的术语。在本综述中，将概述癌前病变的要求、PIN满足这些要求大多数的原因，以及PIN与癌之间形态学和表型相似性的详细描述。最后，将对PIN的临床意义进行综述。
