Ohyama S, Adachi K, Sugawara K, Hongo S, Nishimura H, Kitame F, Nakamura K
Yamagata Prefectural Institute of Public Health, Japan.
Epidemiol Infect. 1992 Apr;108(2):353-65. doi: 10.1017/s0950268800049827.
Eight strains of influenza C virus isolated in various areas of Japan between January 1985 and January 1989 were compared using monoclonal antibodies to the haemagglutinin-esterase (HE) glycoproteins and by oligonucleotide mapping of total vRNA. Five of six strains isolated during 1986-9 were closely related to one another and also resembled the virus, C/Aichi/1/81, isolated in 1981 in Aichi prefecture. This suggests that the C/Aichi/1/81-related viruses had an epidemiological advantage over any co-circulating viruses at least during that period. One of two 1985 isolates (C/Nara/1/85) was antigenically indistinguishable from the C/Mississippi/1/80 strain though their oligonucleotide patterns were markedly different from each other. This raises the possibility that C/Nara/1/85 may be a recombinant virus which receives its HE gene from the C/Mississippi/1/80-related parent.
利用针对血凝素酯酶（HE）糖蛋白的单克隆抗体以及对总病毒RNA（vRNA）进行寡核苷酸图谱分析，对1985年1月至1989年1月间在日本不同地区分离出的8株丙型流感病毒进行了比较。在1986 - 1989年分离出的6株病毒中，有5株彼此密切相关，并且与1981年在爱知县分离出的C/爱知/1/81病毒相似。这表明，至少在那段时期，与C/爱知/1/81相关的病毒相对于任何同时流行的病毒具有流行病学优势。1985年分离出的两株病毒之一（C/奈良/1/85）与C/密西西比/1/80毒株在抗原性上无法区分，尽管它们的寡核苷酸图谱明显不同。这增加了C/奈良/1/85可能是一种重组病毒的可能性，该病毒从与C/密西西比/1/80相关的亲本那里获得了其HE基因。
