Kawamura H, Tashiro M, Kitame F, Homma M, Nakamura K
Virus Res. 1986 May;4(3):275-88. doi: 10.1016/0168-1702(86)90006-7.
The RNA genomes of sixteen human strains of influenza C virus isolated in Japan between 1964 and 1983 were compared by SDS-polyacrylamide gel electrophoresis and oligonucleotide fingerprinting. A high degree of genetic variation was observed among the strains analysed. However, there were some strains with the genomes closely related to one another, and they could be divided into two groups. The first group consists of C/Shizuoka/79, C/Kanagawa/1/81 and four strains of C/Yamagata/81. The 1981 strains of this group were all isolated in March of the year. The second one consists of C/Kyoto/41/82, C/Nara/82 and C/Hyogo/1/83 that were isolated between February 1982 and December 1983. Little or no difference was observed in the genomes of the same group, while the difference was evident between two groups. The Aichi/1/81 strain isolated in November 1981 had a genome distantly related to either of these two groups. Thus three different types of influenza C virus were isolated during the period of 12 mth from March 1981 to February 1982, suggesting that multiple influenza C viruses with distant genetic relationship were circulating at the same time in Japan.
采用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳和寡核苷酸指纹图谱技术，对1964年至1983年间在日本分离出的16株人C型流感病毒的RNA基因组进行了比较。在所分析的毒株中观察到高度的遗传变异。然而，有一些毒株的基因组彼此密切相关，它们可分为两组。第一组包括C/静冈/79、C/神奈川/1/81和4株C/山形/81。该组1981年的毒株均于当年3月分离得到。第二组包括1982年2月至1983年12月期间分离出的C/京都/41/82、C/奈良/82和C/兵库/1/83。同一组毒株的基因组之间几乎没有差异，而两组之间的差异很明显。1981年11月分离出的爱知/1/81毒株的基因组与这两组中的任何一组都有较远的亲缘关系。因此，在1981年3月至1982年2月的12个月期间分离出了三种不同类型的C型流感病毒，这表明在日本同时存在多种具有远缘遗传关系的C型流感病毒。
