Yuanji G, Desselberger U
J Gen Virol. 1984 Nov;65 ( Pt 11):1857-72. doi: 10.1099/0022-1317-65-11-1857.
The genomes of influenza C viruses isolated from pigs in Beijing, China during 1981/82 and of human influenza C virus strains isolated between 1947 and 1981 were analysed by comparison of RNA migration patterns on gels and by two-dimensional oligonucleotide (ON) mapping. The genomes of the pig isolates were closely related to one another, though in part distinguishable by point mutations. They were similar to but more distantly related to the genomes of human influenza C viruses. The genome of the C/pig/Beijing/10/81 isolate differed from that of the C/pig/Beijing/32/81 isolate obtained on the same day at the same place by a number of mutations which were all located in RNA segments 1 and 2 as shown by ON mapping. This result suggests that the two isolates are genetically related by a reassortment event which is likely to have occurred in nature. The question whether or not pigs are a natural reservoir for human influenza C viruses cannot be answered at present.
通过比较凝胶上的RNA迁移模式以及二维寡核苷酸（ON）图谱分析了1981/82年期间从中国北京猪中分离出的C型流感病毒基因组以及1947年至1981年间分离出的人类C型流感病毒株的基因组。猪分离株的基因组彼此密切相关，尽管部分可通过点突变区分。它们与人类C型流感病毒的基因组相似但关系更远。C/猪/北京/10/81分离株的基因组与同一天在同一地点获得的C/猪/北京/32/81分离株的基因组不同，通过ON图谱显示，许多突变都位于RNA片段1和2中。这一结果表明，这两个分离株通过可能在自然中发生的重配事件在基因上相关。目前无法回答猪是否是人类C型流感病毒的天然宿主这一问题。
