Sir Hashim M, Hamza Y O, Yahia B, Khogali F M, Sulieman G I
Department of Paediatrics and Child Health, Faculty of Medicine, University of Khartoum, Sudan.
Ann Trop Paediatr. 1992;12(1):3-6. doi: 10.1080/02724936.1992.11747539.
Poisoning by a mixture of henna dye and para-phenylenediamine dyes led to the hospitalization of 31 Sudanese children between 1984 and 1989. There was a characteristic clinical presentation. All children presented with an acute and severe angioneurotic oedema and 15 of the cases required emergency tracheostomy for respiratory obstruction. Acute renal failure occurred in five children who recovered after peritoneal dialysis. Mortality was high, all 13 deaths occurring within 24 hours of presentation. Hypotensive shock gave a poor prognosis. It is possible that similar cases may be occurring unrecognized where henna is traditionally used. A programme of public education and restriction of para-phenylenediamine is urgently required in The Sudan and other affected nations. Ingestion was accidental in 12 children, deliberate in 10 and homicidal in three cases. Cutaneous absorption was likely in the remaining six.
1984年至1989年间，31名苏丹儿童因指甲花染料和对苯二胺染料混合物中毒而住院。有典型的临床表现。所有儿童均出现急性严重血管神经性水肿，15例因呼吸阻塞需要紧急气管切开术。5名儿童发生急性肾衰竭，经腹膜透析后康复。死亡率很高，13例死亡均发生在就诊后24小时内。低血压性休克预后不良。在传统使用指甲花的地方，可能存在未被识别的类似病例。苏丹和其他受影响国家迫切需要开展公众教育并限制对苯二胺。12名儿童是意外摄入，10名是故意摄入，3例是他杀。其余6例可能是经皮肤吸收。
