Blomgren H
Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
Int J Immunopharmacol. 1992 Feb;14(2):185-90. doi: 10.1016/0192-0561(92)90029-k.
Ru 41.740 (Biostim) is an immunostimulating drug of microbial origin which may stimulate human mononuclear blood cells (mainly monocytes) to release soluble factors which inhibit replication of several tumor cell lines in vitro. Since this effect may be of clinical importance in the treatment of cancer a number of tests have been conducted in order to find methods to augment this secretion. In vitro tests suggested that this non-specific antitumor activity of Biostim may not be enhanced by concomitant treatment of patients with inhibitors of cyclo-oxygenase and lipoxygenases or by interferons alpha, beta, gamma or the hemopoietic growth factors GM-CSF and G-CSF.
Ru 41.740（生物刺激素）是一种微生物来源的免疫刺激药物，它可能刺激人单核血细胞（主要是单核细胞）释放可溶性因子，这些因子在体外可抑制多种肿瘤细胞系的复制。由于这种作用在癌症治疗中可能具有临床重要性，因此已经进行了多项试验以寻找增强这种分泌的方法。体外试验表明，同时用环氧化酶和脂氧化酶抑制剂或α、β、γ干扰素或造血生长因子GM-CSF和G-CSF治疗患者，可能不会增强生物刺激素的这种非特异性抗肿瘤活性。
