Seger R, Buchinger G, Ströder J
Eur J Pediatr. 1977 Jan 26;124(2):77-87. doi: 10.1007/BF00477543.
In 23 subjects of different ages with Down's syndrome a number of parameters of non-specific defense of humoral and cellular immunity were investigated. While in all age groups complement factors C3, C4 and C5 as well as phagocytosis and NBT indices were in the normal range, a dysgammaglobulinaemia increasing with age with a hyperglobulinaemia of the IgG, IgA and IgD types was found, sparing immunoglobulins IgM and IgE. In addition the transformation capacity of peripheral blood lymphocytes decreased with age. This is understood as the consequence of premature aging of the thymus-dependent immune system.
在23名不同年龄段的唐氏综合征患者中，对体液免疫和细胞免疫的一些非特异性防御参数进行了研究。虽然在所有年龄组中，补体因子C3、C4和C5以及吞噬作用和NBT指数均在正常范围内，但发现随着年龄增长出现了γ球蛋白异常血症，伴有IgG、IgA和IgD型的球蛋白血症升高，而免疫球蛋白IgM和IgE未受影响。此外，外周血淋巴细胞的转化能力随年龄下降。这被认为是胸腺依赖性免疫系统过早衰老的结果。
