Gonyea W, Ericson G C, Bonde-Petersen F
Acta Physiol Scand. 1977 Jan;99(1):105-9. doi: 10.1111/j.1748-1716.1977.tb10358.x.
Adult skeletal muscle hypertrophy induced by exercise has been thought to be exclusively related to an increase in cross-section area of individual muscle fibers and not to an increase in the number of muscle fibers. Recent experiments using surgical intervention to cause muscle overload have induced an increase in fiber numbers; however, the muscle also exhibited pathological alterations. The purpose of this study was to determine if an exercise regimen also induced hyperplasia. Cats were trained to lift weights with their right forelimb to receive a food reward. After 19-46 weeks of training, the flexor carpi radialis muscle (FCR) was removed and prepared for histochemical examination. The total number of muscle fibers of the right exercised FCR increased significantly (19.3%) when compared with that of the unexercised left FCR (p less than 0.05). This increase was found to be due to muscle fiber splitting.
运动诱导的成年骨骼肌肥大一直被认为仅与单个肌纤维横截面积的增加有关，而与肌纤维数量的增加无关。最近使用手术干预导致肌肉过载的实验诱导了纤维数量的增加；然而，肌肉也表现出病理改变。本研究的目的是确定运动方案是否也会诱导肌纤维增生。训练猫用右前肢举重以获得食物奖励。训练19 - 46周后，切除桡侧腕屈肌（FCR）并准备进行组织化学检查。与未运动的左侧FCR相比，右侧运动的FCR的肌纤维总数显著增加（19.3%）（p小于0.05）。发现这种增加是由于肌纤维分裂所致。
