重组白细胞介素-6可保护小鼠免受实验性细菌感染。
Recombinant interleukin-6 protects mice against experimental bacterial infection.
作者信息
Liu Z, Simpson R J, Cheers C
机构信息
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Infect Immun. 1992 Oct;60(10):4402-6. doi: 10.1128/iai.60.10.4402-4406.1992.
Abstract
Because of reports of high levels of interleukin-6 (IL-6) in patients during infection, we studied the role of IL-6 in experimental infection. Mice infected with the facultative intracellular pathogen Listeria monocytogenes displayed high levels of IL-6 in their sera and tissues, particularly the spleen, 1 to 3 days after infection. At this time, the IL-6 titers correlated with bacterial numbers in individual mice and in groups of mice given graded doses of Listeria organisms. However, the presence of IL-6 in serum declined after 4 days, even when a large initial dose of bacteria meant that bacterial numbers were still increasing at this time. Recombinant mouse IL-6 injected intraperitoneally before infection protected mice in a dose-dependent manner. It was effective when given 4 h before infection but not when administration was delayed for 24 h postinfection. It is therefore believed that IL-6 plays a role in early priming of the immune response to infection. Its exact function in this model is being investigated.
摘要
由于有报道称感染患者体内白细胞介素-6（IL-6）水平较高，我们研究了IL-6在实验性感染中的作用。感染兼性细胞内病原体单核细胞增生李斯特菌的小鼠在感染后1至3天，其血清和组织，特别是脾脏中显示出高水平的IL-6。此时，IL-6滴度与个体小鼠以及给予不同剂量李斯特菌的小鼠组中的细菌数量相关。然而，4天后血清中IL-6的含量下降，即使最初大量接种细菌意味着此时细菌数量仍在增加。感染前腹腔注射重组小鼠IL-6以剂量依赖的方式保护小鼠。在感染前4小时给药有效，但在感染后延迟24小时给药则无效。因此，人们认为IL-6在感染免疫反应的早期启动中起作用。正在研究其在该模型中的具体功能。
相似文献
1
Recombinant interleukin-6 protects mice against experimental bacterial infection.重组白细胞介素-6可保护小鼠免受实验性细菌感染。
Infect Immun. 1992 Oct;60(10):4402-6. doi: 10.1128/iai.60.10.4402-4406.1992.
2
Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia.白细胞介素-6缺陷小鼠对单核细胞增生李斯特菌感染高度敏感：与中性粒细胞增多效率低下相关。
Infect Immun. 1995 Jun;63(6):2262-8. doi: 10.1128/iai.63.6.2262-2268.1995.
3
The cellular source of interleukin-6 during Listeria infection.李斯特菌感染期间白细胞介素-6的细胞来源。
Infect Immun. 1993 Jun;61(6):2626-31. doi: 10.1128/iai.61.6.2626-2631.1993.
4
Treatment of mice with human recombinant interleukin-2 augments resistance to the facultative intracellular pathogen Listeria monocytogenes.用人重组白细胞介素-2治疗小鼠可增强对兼性细胞内病原体单核细胞增生李斯特菌的抵抗力。
Infect Immun. 1989 Oct;57(10):3014-21. doi: 10.1128/iai.57.10.3014-3021.1989.
5
Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection.重组白细胞介素-12增强小鼠对单核细胞增生李斯特菌感染的抵抗力。
Microb Pathog. 1994 Sep;17(3):175-86. doi: 10.1006/mpat.1994.1064.
6
Role of IL-6 in activation of T cells for acquired cellular resistance to Listeria monocytogenes.白细胞介素-6在激活T细胞以获得对单核细胞增生李斯特菌的细胞性抗性中的作用。
J Immunol. 1994 Jun 1;152(11):5375-80.
7
Protection by dexamethasone from a lethal infection with Listeria monocytogenes in mice.地塞米松对小鼠单核细胞增生李斯特菌致死性感染的保护作用。
FEMS Immunol Med Microbiol. 1994 Aug;9(2):163-70. doi: 10.1111/j.1574-695X.1994.tb00487.x.
8
Effects of IL-13 on murine listeriosis.白细胞介素-13对小鼠李斯特菌病的影响。
Int Immunol. 1997 Apr;9(4):467-74. doi: 10.1093/intimm/9.4.467.
9
Immunohematopoietic modulation by oral β-1,3-glucan in mice infected with Listeria monocytogenes.口服 β-1,3-葡聚糖对感染李斯特菌单核细胞增生症小鼠的免疫血液调节作用。
Int Immunopharmacol. 2010 Dec;10(12):1573-9. doi: 10.1016/j.intimp.2010.09.009. Epub 2010 Oct 15.
10
Interleukin-1 receptor type 1 is essential for control of cerebral but not systemic listeriosis.白细胞介素-1受体1型对于控制脑内李斯特菌病至关重要，但对全身性李斯特菌病则并非如此。
Am J Pathol. 2007 Mar;170(3):990-1002. doi: 10.2353/ajpath.2007.060507.
引用本文的文献
1
Innate and Adaptive Immune Responses during Infection.感染期间的先天和适应性免疫反应。
Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.GPP3-0065-2019.
2
Association of a placental Interleukin-6 genetic variant (rs1800796) with DNA methylation, gene expression and risk of acute chorioamnionitis.胎盘白细胞介素 6 基因变异（rs1800796）与 DNA 甲基化、基因表达和急性绒毛膜羊膜炎风险的关联。
BMC Med Genet. 2019 Feb 22;20(1):36. doi: 10.1186/s12881-019-0768-0.
3
Ginkgo biloba extract reduces high-glucose-induced endothelial adhesion by inhibiting the redox-dependent interleukin-6 pathways.银杏叶提取物通过抑制氧化还原依赖的白细胞介素-6 途径减少高糖诱导的内皮细胞黏附。
Cardiovasc Diabetol. 2012 May 3;11:49. doi: 10.1186/1475-2840-11-49.
4
The protective and immunomodulatory effects of hypothalamic proline-rich polypeptide galarmin against methicillin-resistant Staphylococcus aureus infection in mice.下丘脑脯氨酸丰富多肽 galarmin 对耐甲氧西林金黄色葡萄球菌感染小鼠的保护和免疫调节作用。
Eur J Clin Microbiol Infect Dis. 2012 Sep;31(9):2153-65. doi: 10.1007/s10096-012-1550-9. Epub 2012 Feb 11.
5
The ubiquitous interleukin-6: a time for reappraisal.无处不在的白细胞介素 6：重新评估的时刻。
Cardiovasc Diabetol. 2010 Oct 11;9:62. doi: 10.1186/1475-2840-9-62.
6
Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance.发热范围热应激对淋巴细胞-内皮细胞-IL-6转信号轴的调节：免疫监视的热点
Cytokine. 2007 Jul;39(1):84-96. doi: 10.1016/j.cyto.2007.07.184.
7
A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses.一种具有通用结构的完全合成疫苗，其靶向树突状细胞上的Toll样受体2，并促进抗体或细胞毒性T细胞反应。
Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15440-5. doi: 10.1073/pnas.0406740101. Epub 2004 Oct 15.
8
Epigallocatechin gallate, a potential immunomodulatory agent of tea components, diminishes cigarette smoke condensate-induced suppression of anti-Legionella pneumophila activity and cytokine responses of alveolar macrophages.表没食子儿茶素没食子酸酯是茶叶成分中的一种潜在免疫调节剂，可减轻香烟烟雾凝聚物诱导的对肺泡巨噬细胞抗嗜肺军团菌活性和细胞因子反应的抑制作用。
Clin Diagn Lab Immunol. 2002 Jul;9(4):864-71. doi: 10.1128/cdli.9.4.864-871.2002.
9
Interleukin-6 regulates the phenotype of the immune response to a tuberculosis subunit vaccine.白细胞介素-6调节对结核亚单位疫苗免疫反应的表型。
Immunology. 2001 Jul;103(3):375-81. doi: 10.1046/j.1365-2567.2001.01244.x.
10
Effects of exogenous interleukin-6 during Pseudomonas aeruginosa corneal infection.铜绿假单胞菌角膜感染期间外源性白细胞介素-6的作用
Infect Immun. 2001 Jun;69(6):4116-9. doi: 10.1128/IAI.69.6.4116-4119.2001.
本文引用的文献
1
On the mechanism of T cell-independent anti-Listeria resistance in nude mice.关于裸鼠中T细胞非依赖性抗李斯特菌抗性的机制
J Immunol. 1980 Feb;124(2):571-6.
2
Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon.重组免疫干扰素对小鼠抗细胞内细菌单核细胞增生李斯特菌的保护作用。
Eur J Immunol. 1984 Oct;14(10):964-7. doi: 10.1002/eji.1830141019.
3
Colony-forming cells and colony-stimulating activity during listeriosis in genetically resistant or susceptible mice.基因抗性或易感小鼠感染李斯特菌病期间的集落形成细胞和集落刺激活性
Cell Immunol. 1986 Feb;97(2):227-37. doi: 10.1016/0008-8749(86)90393-x.
4
Antibacterial activity of recombinant murine beta interferon.重组小鼠β干扰素的抗菌活性
Infect Immun. 1988 Mar;56(3):548-51. doi: 10.1128/iai.56.3.548-551.1988.
5
6
Characterization of a recombinant murine interleukin-6: assignment of disulfide bonds.一种重组小鼠白细胞介素-6的特性鉴定：二硫键的确定
Biochem Biophys Res Commun. 1988 Nov 30;157(1):364-72. doi: 10.1016/s0006-291x(88)80056-1.
7
Macrophage production during murine listeriosis: colony-stimulating factor 1 (CSF-1) and CSF-1-binding cells in genetically resistant and susceptible mice.小鼠李斯特菌病期间巨噬细胞的产生：基因抗性和易感小鼠中的集落刺激因子1（CSF-1）及CSF-1结合细胞
Infect Immun. 1988 Nov;56(11):2972-8. doi: 10.1128/iai.56.11.2972-2978.1988.
8
B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.B细胞刺激因子-2参与细胞毒性T淋巴细胞的分化。
J Immunol. 1988 Jan 15;140(2):508-12.
9
Production of colony-stimulating factors (CSFs) during infection: separate determinations of macrophage-, granulocyte-, granulocyte-macrophage-, and multi-CSFs.感染期间集落刺激因子（CSF）的产生：巨噬细胞集落刺激因子、粒细胞集落刺激因子、粒细胞-巨噬细胞集落刺激因子和多能集落刺激因子的单独测定
Infect Immun. 1988 Jan;56(1):247-51. doi: 10.1128/iai.56.1.247-251.1988.
10
The in vitro bactericidal activity of peritoneal and spleen cells from Listeria-resistant and -susceptible mouse strains.来自对李斯特菌有抗性和易感性的小鼠品系的腹膜和脾脏细胞的体外杀菌活性。
Cell Immunol. 1986 Apr 15;99(1):160-9. doi: 10.1016/0008-8749(86)90225-x.
Zotero 插件