Liu Z, Simpson R J, Cheers C
Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.
Infect Immun. 1992 Oct;60(10):4402-6. doi: 10.1128/iai.60.10.4402-4406.1992.
Because of reports of high levels of interleukin-6 (IL-6) in patients during infection, we studied the role of IL-6 in experimental infection. Mice infected with the facultative intracellular pathogen Listeria monocytogenes displayed high levels of IL-6 in their sera and tissues, particularly the spleen, 1 to 3 days after infection. At this time, the IL-6 titers correlated with bacterial numbers in individual mice and in groups of mice given graded doses of Listeria organisms. However, the presence of IL-6 in serum declined after 4 days, even when a large initial dose of bacteria meant that bacterial numbers were still increasing at this time. Recombinant mouse IL-6 injected intraperitoneally before infection protected mice in a dose-dependent manner. It was effective when given 4 h before infection but not when administration was delayed for 24 h postinfection. It is therefore believed that IL-6 plays a role in early priming of the immune response to infection. Its exact function in this model is being investigated.
由于有报道称感染患者体内白细胞介素-6（IL-6）水平较高，我们研究了IL-6在实验性感染中的作用。感染兼性细胞内病原体单核细胞增生李斯特菌的小鼠在感染后1至3天，其血清和组织，特别是脾脏中显示出高水平的IL-6。此时，IL-6滴度与个体小鼠以及给予不同剂量李斯特菌的小鼠组中的细菌数量相关。然而，4天后血清中IL-6的含量下降，即使最初大量接种细菌意味着此时细菌数量仍在增加。感染前腹腔注射重组小鼠IL-6以剂量依赖的方式保护小鼠。在感染前4小时给药有效，但在感染后延迟24小时给药则无效。因此，人们认为IL-6在感染免疫反应的早期启动中起作用。正在研究其在该模型中的具体功能。
