弗氏佐剂和肺炎溶血素免疫对大鼠体内肺炎球菌感染肺组织学特征的影响。
Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo.
作者信息
Roberts P, Jeffery P K, Mitchell T J, Andrew P W, Boulnois G J, Feldman C, Cole P J, Wilson R
机构信息
Department of Thoracic Medicine, Royal Brompton National Heart and Lung Institute, London, United Kingdom.
出版信息
Infect Immun. 1992 Nov;60(11):4969-72. doi: 10.1128/iai.60.11.4969-4972.1992.
Abstract
Immunization with Freund's adjuvant and pneumolysin and stimulation with Freund's adjuvant alone both reduced the severity of the pneumonia caused by injections of bacteria into the apical lobe bronchi of rats. Neither protocol influenced the incidence of pneumococcal bacteremia. Illness sufficiently severe to require sacrifice was delayed from 2.8 days in nonimmunized animals to 5.7 days in those immunized with Freund's adjuvant and pneumolysin (P < 0.05) and 4.5 days in those stimulated with Freund's adjuvant alone (P, not significant).
摘要
用弗氏佐剂和肺炎溶血素进行免疫以及仅用弗氏佐剂刺激，均可减轻向大鼠肺尖叶支气管注射细菌所致肺炎的严重程度。两种方案均未影响肺炎球菌菌血症的发生率。病情严重到需要处死动物的时间，从未免疫动物的2.8天推迟到用弗氏佐剂和肺炎溶血素免疫动物的5.7天（P<0.05），以及仅用弗氏佐剂刺激动物的4.5天（P，无显著性差异）。
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