Shonat R D, Wilson D F, Riva C E, Cranstoun S D
Department of Ophthalmology, Scheie Eye Institute, Philadelphia, PA 19104.
Invest Ophthalmol Vis Sci. 1992 Oct;33(11):3174-80.
A newly developed phosphorescence imaging technique was used to generate two-dimensional maps of intravascular oxygen tension (PO2) in the optic nerve head (ONH) and retina of the cat to study the effects of acute moderate increases in intraocular pressure (IOP) on the ONH and retinal PO2. Both the ONH and retinal PO2 were remarkably well maintained as the IOP increased; hypoxia developed only after the blood flow to the eye was stopped. Because ONH hypoxia was not observed during IOP elevation, a lack of oxygen may not be a major cause of glaucomatous damage, although the effects of chronically elevated IOP on the PO2 remain to be evaluated. Because this imaging technique was noninvasive and required only a small bolus injection of a nontoxic oxygen probe, the authors anticipate that it will find significant application in the study of many ocular vascular diseases and glaucoma.
一种新开发的磷光成像技术被用于生成猫视神经乳头（ONH）和视网膜内血管氧张力（PO2）的二维图谱，以研究眼内压（IOP）急性适度升高对视神经乳头和视网膜PO2的影响。随着眼内压升高，视神经乳头和视网膜的PO2均得到显著良好的维持；仅在眼部血流停止后才出现缺氧。由于在眼内压升高期间未观察到视神经乳头缺氧，因此尽管长期升高的眼内压对PO2的影响仍有待评估，但缺氧可能不是青光眼性损伤的主要原因。由于这种成像技术是非侵入性的，并且只需要小剂量注射无毒的氧探针，作者预计它将在许多眼部血管疾病和青光眼的研究中得到重要应用。
