Grønlund J, Kofoed H, Svalastoga E
Acta Physiol Scand. 1984 Jun;121(2):127-31. doi: 10.1111/j.1748-1716.1984.tb07438.x.
We have investigated the influence of acute changes in the knee joint pressure of rabbits on the oxygen tension and the regional blood flow in the subchondral bone. The intra-articular pressure was increased by infusion of a sodium chloride solution into the joint cavity, and the associated change in the subchondral oxygen tension was measured by mass spectrometry. The mass spectrometer was also used to detect, qualitatively, changes in the regional blood flow. When the joint pressure was increased from the habitual level to 75 mmHg, the average subchondral oxygen tension was reduced from about 39 to about 30 mmHg and, at the same time, the regional blood flow was reduced significantly.
我们研究了兔膝关节压力急性变化对软骨下骨氧张力和局部血流的影响。通过向关节腔注入氯化钠溶液来增加关节内压力，并用质谱法测量软骨下氧张力的相关变化。质谱仪还用于定性检测局部血流的变化。当关节压力从习惯水平增加到75 mmHg时，软骨下平均氧张力从约39 mmHg降至约30 mmHg，同时局部血流显著减少。
