Molla A M, Bari A
Department of Paediatrics, Aga Khan University, Karachi, Pakistan.
Acta Paediatr Suppl. 1992 Sep;381:104-7. doi: 10.1111/j.1651-2227.1992.tb12381.x.
A total of 2000 children aged under five and 12,500 diarrhoea episodes were studied prospectively for assessing the efficacies of R-ORS and G-ORS and for comparing them with that of a comparison area using drugs for treatment. Efficacy was evaluated in terms of ORS use rate, consumption of ORS per episode, duration of diarrhoea and rate of recovery. The data were analysed to compare the rate of persistent diarrhoea in the three areas. Mean ORS consumption was 946 +/- 576 and 1236 +/- 766 ml per episode of watery diarrhoea in the R-ORS and G-ORS areas respectively. The mean durations of watery diarrhoea were 3.3 +/- 2.1, 5.4 +/- 3.5 and 8.8 +/- 5.5 days in the R-ORS, G-ORS and comparison area, respectively. The median durations for dysentery were 7, 9 and 12 days in the three areas respectively. The incidences of persistent diarrhoea following water diarrhoea were 0.4, 3 and 12% in the R-ORS, G-ORS and comparison area respectively, and, following dysenteric episodes, 8, 18 and 40%. The results of the study suggest that R-ORS can hasten recovery from both watery diarrhoea and dysenteries, thus reducing the incidence of persistent diarrhoea.
对2000名五岁以下儿童和12500例腹泻病例进行了前瞻性研究，以评估大米口服补液盐（R-ORS）和葡萄糖口服补液盐（G-ORS）的疗效，并将它们与使用药物治疗的对照地区进行比较。根据口服补液盐使用率、每次腹泻口服补液盐消耗量、腹泻持续时间和恢复率来评估疗效。分析数据以比较三个地区持续性腹泻的发生率。在R-ORS地区和G-ORS地区，水样腹泻每次发作的口服补液盐平均消耗量分别为946±576毫升和1236±766毫升。R-ORS地区、G-ORS地区和对照地区水样腹泻的平均持续时间分别为3.3±2.1天、5.4±3.5天和8.8±5.5天。三个地区痢疾的中位数持续时间分别为7天、9天和12天。水样腹泻后持续性腹泻的发生率在R-ORS地区、G-ORS地区和对照地区分别为0.4%、3%和12%，痢疾发作后分别为8%、18%和40%。研究结果表明，R-ORS可以加速水样腹泻和痢疾的恢复，从而降低持续性腹泻的发生率。
