Yoshida K, Kobayashi K, Yamagata N, Iwabuchi H, Katsura T, Sugihara S, Negishi M, Ide H, Mori Y, Takahashi T
First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Int Arch Allergy Immunol. 1992;98(4):286-92. doi: 10.1159/000236200.
Cytokines and lysosomal enzymes, which are produced by inflammatory cells, play a role in inflammation. We have found that synovial fluid (SF) in rheumatoid and septic arthritis contained a large number of white blood cells (WBCs) and high levels of cytokines and enzymes, while in contrast the SF of osteoarthritis and traumatic arthritis did not contain significant amounts. Measurements of WBCs, cytokines and enzymes in SF are useful for evaluating clinical disease activity. Assays for WBCs and enzymes are simple and rapid when compared to those for cytokines.
由炎症细胞产生的细胞因子和溶酶体酶在炎症中起作用。我们发现，类风湿性关节炎和感染性关节炎的滑液（SF）中含有大量白细胞（WBC）以及高水平的细胞因子和酶，而相比之下，骨关节炎和创伤性关节炎的滑液中含量并不显著。测量滑液中的白细胞、细胞因子和酶有助于评估临床疾病活动度。与细胞因子检测相比，白细胞和酶的检测简单且快速。
