Rico H, Revilla M, Hernandez E R, Villa L F, Alvarez del Buergo M
Department of Medicine, Príncipe de Asturias Hospital, Alcalá de Henares University, Madrid, Spain.
Calcif Tissue Int. 1992 Oct;51(4):251-4. doi: 10.1007/BF00334483.
Dual energy X-ray absorptiometry evaluation of total body bone mineral content (TBBM), total bone mineral density (TBMD), and regional bone mineral content (BMC) (head, trunk, arms, and legs) was carried out in order to assess sex differences of bone in 120 women and 121 men aged 15-29 years. Subjects from both sexes were divided into 5-year groups (15 through 19, 20 through 24, and 25 through 29 years old, respectively). Significantly higher values for TBBM, TBMD, and regional BMC were observed in males compared with females in the 20 to 24 and 25 to 29-year-old groups (P less than 0.001), but not in the group aged 15-19. After adjusting TBBM for lean body mass (LBM), we observed significantly lower values of TBBM/LBM in the males compared with females in all the age groups. A positive and significant correlation was observed between TBBM and age in the males of all the groups (r = 0.624, P less than 0.001), but not in the females. These data suggest that total bone mass peak acquisition takes place earlier in women than in men, leading to more reduced bone mass value, which in turn may be an osteoporosis predisposing factor.
为评估120名15至29岁女性和121名同龄男性的骨骼性别差异，采用双能X线吸收法对全身骨矿物质含量（TBBM）、总骨矿物质密度（TBMD）和局部骨矿物质含量（BMC）（头部、躯干、手臂和腿部）进行了测量。将男女受试者按5岁一组进行划分（分别为15至19岁、20至24岁和25至29岁）。在20至24岁和25至29岁年龄组中，男性的TBBM、TBMD和局部BMC值显著高于女性（P<0.001），但在15至19岁年龄组中并非如此。在对TBBM进行去脂体重（LBM）校正后，我们发现所有年龄组中男性的TBBM/LBM值均显著低于女性。在所有年龄组的男性中，TBBM与年龄之间均呈现显著正相关（r = 0.624，P<0.001），而女性则不然。这些数据表明，女性全身骨量峰值获取比男性更早，导致骨量值降低更多，这反过来可能是骨质疏松的一个易感因素。
