Stankus S J, Johnson N T
Madigan Army Medical Center, Department of Family Practice, Fort Lewis, WA 98431-5000.
Chest. 1992 Nov;102(5):1595-6. doi: 10.1378/chest.102.5.1595.
Hypersensitivity vasculitis associated with propylthiouracil therapy is a well-documented clinical entity. Although any organ system may be involved, it is most unusual for pulmonary manifestations to be the cardinal presenting features. We report a 72-year-old woman presenting with respiratory failure and hemoptysis following initiation of propylthiouracil therapy for Graves' disease. She had cutaneous stigmata of hypersensitivity vasculitis and diffuse pulmonary infiltrates. The infiltrates improved dramatically after discontinuation of the propylthiouracil therapy and initiation of intravenous corticosteroid therapy.
与丙硫氧嘧啶治疗相关的超敏性血管炎是一种有充分文献记载的临床病症。尽管任何器官系统都可能受累，但肺部表现作为主要首发特征是极不常见的。我们报告一名72岁女性，在开始使用丙硫氧嘧啶治疗格雷夫斯病后出现呼吸衰竭和咯血。她有超敏性血管炎的皮肤体征和弥漫性肺部浸润。停用丙硫氧嘧啶治疗并开始静脉注射皮质类固醇治疗后，浸润明显改善。
