在需氧和厌氧条件下培养的粪便悬浮液中5-氨基水杨酸的细菌乙酰化作用。
Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions.
作者信息
van Hogezand R A, Kennis H M, van Schaik A, Koopman J P, van Hees P A, van Tongeren J H
机构信息
Department of Medicine, St. Radboud Hospital, Nijmegen, The Netherlands.
出版信息
Eur J Clin Pharmacol. 1992;43(2):189-92. doi: 10.1007/BF01740669.
After oral administration of 5-aminosalicylic acid a substantial proportion of the acetylated form is excreted in the faeces. We have studied the role of the faecal microflora in acetylating 5-aminosalicylic acid. In faeces incubated under both aerobic and anaerobic conditions there was acetylation of 5-aminosalicylic acid. Of the anaerobic bacteria isolated from a 10(8) faecal dilution 44% were able to acetylate 5-aminosalicylic acid. We conclude that the normal faecal microflora contribute to the acetylation of 5-aminosalicylic acid.
口服5-氨基水杨酸后，相当一部分乙酰化形式经粪便排出。我们研究了粪便微生物群在5-氨基水杨酸乙酰化过程中的作用。在需氧和厌氧条件下孵育的粪便中，均有5-氨基水杨酸的乙酰化现象。从10⁸倍粪便稀释液中分离出的厌氧菌中，44%能够使5-氨基水杨酸乙酰化。我们得出结论，正常粪便微生物群有助于5-氨基水杨酸的乙酰化。
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