Yambe T, Nitta S, Katahira Y, Sonobe T, Naganuma S, Akiho H, Kakinuma Y, Izutzu K, Kikuchi Y, Naganuma T
Department of Medical Engineering and Cardiology, School of Medicine, Tohoku University, Sendai, Japan.
Int J Artif Organs. 1992 Oct;15(10):606-10.
A sympathetic neurogram is potentially useful for the development of a real time total artificial heart (TAH) control system. We used sympathetic tone and hemodynamic derivatives to estimate the following cardiac output in acute animal experiments using adult mongrel dogs. Moving averages of the mean left atrial pressure and mean aortic pressure were used as parameters of the preload and afterload, respectively. Renal sympathetic nerve activity (RSNA) was employed as a parameter of sympathetic tone. Equations for the following cardiac output were calculated using multiple linear regression analysis of the time series data. A significant correlation was observed between the estimated and following measured cardiac output. These results suggest the potential usefulness of the sympathetic neurogram for the real time TAH automatic control system.
交感神经电图对于实时全人工心脏（TAH）控制系统的开发可能具有重要价值。在使用成年杂种犬进行的急性动物实验中，我们利用交感神经张力和血流动力学导数来估算后续的心输出量。平均左心房压和平均主动脉压的移动平均值分别用作前负荷和后负荷的参数。肾交感神经活动（RSNA）被用作交感神经张力的参数。通过对时间序列数据进行多元线性回归分析，计算出后续心输出量的方程。在估算的心输出量与后续测量的心输出量之间观察到显著相关性。这些结果表明交感神经电图对于实时TAH自动控制系统具有潜在的应用价值。
