Petursdottir V, Jonasson J G, Hrafnkelsson J
Department of Pathology, University of Iceland, Reykjavík.
APMIS. 1992 Oct;100(10):942-8.
We studied all primary malignancies of the oesophagus diagnosed in Iceland between 1955 and 1984 and reclassified tumours where histological material was available using the WHO classification system. Of a total of 329 tumours diagnosed in the time period, seven were excluded for various reasons. Of the remaining 322 tumours, 178 were in males and 144 in females. The age standardized incidence was 5.3/10(5) for males and 3.1/10(5) for females. The incidence of oesophageal tumours decreased for both sexes during the time period under investigation. Of 250 reclassified tumours (142 in males and 108 in females), squamous cell carcinomas comprised 81.6%. If the undifferentiated tumours are excluded, the squamous group accounted for 89.1% of the remaining tumours. Small cell carcinomas comprised 3.2% of all cases, which was higher than expected. Most of the tumours appear to be located in the middle part of the oesophagus. The vast majority of resected tumours extended through the wall of the oesophagus. A relatively higher proportion of tumours was confined to the submucosal or muscular layers in the latter half of the period. In conclusion, the epidemiological data in our study appear to resemble what is observed in the other Nordic countries for oesophageal tumours, except for slightly higher overall incidence in Iceland, especially for women.
我们研究了1955年至1984年间冰岛诊断出的所有原发性食管癌，并对有组织学材料的肿瘤使用世界卫生组织分类系统进行重新分类。在该时间段诊断出的总共329例肿瘤中，因各种原因排除了7例。在其余322例肿瘤中，男性178例，女性144例。男性年龄标准化发病率为5.3/10⁵，女性为3.1/10⁵。在调查期间，两性食管癌发病率均有所下降。在250例重新分类的肿瘤中（男性142例，女性108例），鳞状细胞癌占81.6%。如果排除未分化肿瘤，鳞状细胞癌组占其余肿瘤的89.1%。小细胞癌占所有病例的3.2%，高于预期。大多数肿瘤似乎位于食管中部。绝大多数切除的肿瘤已穿透食管壁。在该时期后半段，局限于黏膜下层或肌层的肿瘤比例相对较高。总之，我们研究中的流行病学数据似乎与其他北欧国家食管癌的情况相似，只是冰岛的总体发病率略高，尤其是女性。
