[多种苯二氮䓬类药物对人红细胞的抗溶血作用]
[Antihemolytic effect of various benzodiazepines on human erythrocytes].
作者信息
Terhaag B, Bockisch A
出版信息
Acta Biol Med Ger. 1976;35(10):1415-7.
PMID:14466
Abstract
The benzodiazepines, medazepam, chlorodiazepoxyde, and oxazepam, act antihemolytically just as chloropromazine in hypotonic NaCl solution on human erythrocytes. The effect depends on concentration and is biphasic with the exception of oxazepam. The maximal antihemolytic concentrations are for medazepam 9.1-10-5 M, for chlorodiazepoxyde 4.6-10-4 M and, respectively, 9.1-10-4 M for diazepam and oxazepam. No linear correlation exists between the concentration at maximal hemolytic protection and the lipid solubility.
摘要
苯二氮䓬类药物，美达西泮、氯氮䓬和奥沙西泮，在低渗氯化钠溶液中对人红细胞的抗溶血作用与氯丙嗪相同。除奥沙西泮外，该作用取决于浓度且呈双相性。最大抗溶血浓度，美达西泮为9.1×10⁻⁵ M，氯氮䓬为4.6×10⁻⁴ M，地西泮和奥沙西泮分别为9.1×10⁻⁴ M。最大溶血保护浓度与脂溶性之间不存在线性相关性。
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