Golshan M, Nematbakhsh M, Amra B, Crapo R O
Dept of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Eur Respir J. 2003 Sep;22(3):529-34. doi: 10.1183/09031936.03.00003603.
Ethnic differences in pulmonary function have been frequently reported. The purposes of this study were to derive equations for the prediction of normative spirometry values for a large population of Persians in Isfahan and compare them to reference values from a White Euro-USA population. Spirometry measurements were obtained from 4,341 randomly selected healthy nonsmoker subjects in Isfahan, Iran, utilising American Thoracic Society guidelines and a vigorous quality assurance program. Measured data from 3,213 subjects were analysed using multiple regression techniques to derive prediction equations for spirometric variables; the remaining 1,128 subjects were used as a control group to test the validity of the derived equations. In addition, predicted values were compared with values derived from recently published equations for the USA. Derived prediction equations showed good performance for most spirometric parameters. Compared with USA Whites, adult Persians have minimally lower forced vital capacities, while the values for children are close to USA Whites. In comparison with reference equations based on European or USA populations, local reference values are more biologically and technically suitable for the interpretation of spirometric data from Iranian populations.
肺功能的种族差异已被频繁报道。本研究的目的是推导用于预测伊斯法罕大量波斯人群标准肺活量测定值的方程，并将其与来自白种欧美人群的参考值进行比较。使用美国胸科学会指南和严格的质量保证程序，从伊朗伊斯法罕随机选取4341名健康非吸烟受试者进行肺活量测定。使用多元回归技术对3213名受试者的测量数据进行分析，以推导肺活量测定变量的预测方程；其余1128名受试者作为对照组，以检验所推导方程的有效性。此外，将预测值与美国最近发表的方程得出的值进行比较。所推导的预测方程对大多数肺活量测定参数表现良好。与美国白人相比，成年波斯人的用力肺活量略低，而儿童的值与美国白人接近。与基于欧洲或美国人群的参考方程相比，本地参考值在生物学和技术上更适合解释伊朗人群的肺活量测定数据。
