Wistar大鼠和人类结肠不同部位的隐窝细胞生成率。
Crypt cell production rates at various sites around the colon in Wistar rats and humans.
作者信息
Hall C, Youngs D, Keighley M R
机构信息
Department of Surgery, Birmingham General Hospital.
出版信息
Gut. 1992 Nov;33(11):1528-31. doi: 10.1136/gut.33.11.1528.
Abstract
The crypt cell production rate (CCPR) is considered the most robust estimate of cell turnover. The CCPR was determined at various sites around the colon in the Wistar rat (using an in vivo technique) and in six healthy humans (using in vitro organ culture). In both the rat and human colon, the CCPR increased proximally from the rectum to the caecum. The caecum had a significantly higher cell turnover than any other site in the colon (p < 0.05 in the rat, p < 0.01 in humans, Student's t test). These findings are of interest when considering cellular proliferation studies in both inflammatory bowel disease and colorectal cancer, and draw attention to the importance of choosing a constant reference site for comparative studies. This is the first time the CCPR had been measured along the length of the human colon.
摘要
隐窝细胞产生率（CCPR）被认为是对细胞更新最可靠的估计。在Wistar大鼠中（采用体内技术）以及在六名健康人类中（采用体外器官培养），在结肠周围的不同部位测定了CCPR。在大鼠和人类结肠中，CCPR均从直肠向盲肠近端增加。盲肠的细胞更新明显高于结肠中的任何其他部位（大鼠中p < 0.05，人类中p < 0.01，学生t检验）。在考虑炎症性肠病和结直肠癌的细胞增殖研究时，这些发现很有意义，并提请注意在比较研究中选择一个恒定参考部位的重要性。这是首次沿人类结肠长度测量CCPR。
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