Gladden Andrew B, Diehl J Alan
The Leonard and Madlyn Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Family Cancer Center of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Cancer Cell. 2003 Sep;4(3):160-2. doi: 10.1016/s1535-6108(03)00217-4.
G1 is the phase of the cell cycle wherein the cell is responsive to growth factor-dependent signals. As such, G1 regulation is frequently disrupted in cancer through deregulation of cyclin/CDK activity; deregulation of G1 phase provides tumorigenic cells with a growth advantage. Cyclin E, the regulatory cyclin for CDK2, is considered a requisite regulator of G1 progression. Cyclin E is overexpressed in cancer, suggesting that cyclin E/CDK2 deregulation contributes to tumorigenesis. Two papers now challenge both the concept that cyclin E/CDK2 is a requisite component of the cell cycle machine and efforts to develop cyclin E/CDK2 inhibitors as antiproliferative therapeutics.
G1期是细胞周期中的一个阶段，在此阶段细胞对依赖生长因子的信号有反应。因此，在癌症中，G1调控常常因细胞周期蛋白/细胞周期蛋白依赖性激酶（CDK）活性失调而被破坏；G1期失调为致瘤细胞提供了生长优势。细胞周期蛋白E是CDK2的调节性细胞周期蛋白，被认为是G1期进程的必要调节因子。细胞周期蛋白E在癌症中过度表达，这表明细胞周期蛋白E/CDK2失调促成了肿瘤发生。现在有两篇论文对细胞周期蛋白E/CDK2是细胞周期机制的必要组成部分这一概念以及开发细胞周期蛋白E/CDK2抑制剂作为抗增殖疗法的努力提出了挑战。
