精胺和亚精胺的一个推测功能：保护复制中的DNA免受单线态氧的损伤。
A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen.
作者信息
Khan A U, Mei Y H, Wilson T
机构信息
Department of Pathology, Harvard Medical School, Boston, MA 02115.
出版信息
Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11426-7. doi: 10.1073/pnas.89.23.11426.
Abstract
Like all aliphatic amines, the polyamines spermine and spermidine are physical quenchers of singlet molecular oxygen (1O2*). The rate constants of these processes were determined in vitro with photochemically generated 1O2* and the hydrocarbon rubrene as substrate, in pyridine. At millimolar concentration, spermine and spermidine should quench 1O2* in vivo and prevent it from damaging DNA. It is proposed that a biological function of polyamines is the protection of replicating DNA against oxidative damage.
摘要
与所有脂肪族胺一样，多胺精胺和亚精胺是单线态分子氧（1O2*）的物理猝灭剂。这些过程的速率常数是在体外以光化学产生的1O2和烃类红荧烯作为底物，在吡啶中测定的。在毫摩尔浓度下，精胺和亚精胺应在体内猝灭1O2并防止其损伤DNA。有人提出，多胺的生物学功能是保护复制中的DNA免受氧化损伤。
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