成体神经干细胞的生态位。

A niche for adult neural stem cells.

作者信息

Doetsch Fiona

机构信息

Harvard University, Department of Molecular and Cellular Biology, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

出版信息

Curr Opin Genet Dev. 2003 Oct;13(5):543-50. doi: 10.1016/j.gde.2003.08.012.

DOI:10.1016/j.gde.2003.08.012

PMID:14550422

Abstract

The adult mammalian brain harbors multipotent stem cells, which reside and participate in specialized niches that support self-renewal and differentiation. The first cellular and molecular elements of the stem cell niche in the adult brain have been identified and include cell-cell interactions and somatic cell signaling, the vasculature, the extracellular matrix and basal lamina. Furthermore, regulation at the epigenetic level via chromatin modification and remodeling is an integral aspect of stem cell biology. Understanding the in vivo stem cell niche will provide a framework for the elucidation of stem cell function in the adult brain.

摘要

成年哺乳动物的大脑中存在多能干细胞，这些干细胞存在于特定的微环境中，并参与支持自我更新和分化的过程。成年大脑中干细胞微环境的首批细胞和分子成分已被确定，包括细胞间相互作用和体细胞信号传导、脉管系统、细胞外基质和基膜。此外，通过染色质修饰和重塑在表观遗传水平上的调控是干细胞生物学的一个重要方面。了解体内干细胞微环境将为阐明成年大脑中干细胞的功能提供一个框架。