van der Woude Hester, Gliszczyńska-Swigło Anna, Struijs Karin, Smeets Astrid, Alink Gerrit M, Rietjens Ivonne M C M
Division of Toxicology, Wageningen University, 6703 HE, Wageningen, The Netherlands.
Cancer Lett. 2003 Oct 8;200(1):41-7. doi: 10.1016/s0304-3835(03)00412-9.
Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect.
确定了槲皮素溶解度和稳定性的最佳体外条件。利用这些条件，研究了槲皮素对结肠癌细胞系HCT-116和HT29以及乳腺腺癌细胞系MCF-7增殖的影响。对于结肠癌细胞系，在相对较高的浓度下，观察到细胞增殖显著下降，这为槲皮素抗癌活性的说法提供了依据。然而，在较低浓度下，所有测试的细胞系均观察到细胞增殖有轻微但显著的刺激作用。这些结果表明槲皮素对细胞增殖具有二元影响，这可能会影响目前对其假定的有益抗增殖作用的看法。
