Agullo G, Gamet-Payrastre L, Fernandez Y, Anciaux N, Demigné C, Rémésy C
Laboratoire des Maladies Métaboliques, INRA de Theix, Ceyrat, France.
Cancer Lett. 1996 Jul 19;105(1):61-70. doi: 10.1016/0304-3835(96)04262-0.
The aim of the present study was to compare the effect of five structural classes of flavonoids on the viability and metabolism of a colonic adenocarcinoma cell line (HT29 cells). The most prominent structural features of flavonoids favoring both their cytotoxic activity and their capacity to inhibit lactate release appear to be the desaturation of the 2, 3 bond and the position of attachment of the B ring. Indeed, flavonol and flavone are the most potent and, in both classes, the order of potency can be modulated by hydroxyl or methoxyl substituents. On the other hand, in our model, we did not find any correlation between flavonoid structure and their capacity to modulate cAMP level. This last point is discussed.
本研究的目的是比较五类黄酮类化合物对结肠腺癌细胞系（HT29细胞）活力和代谢的影响。黄酮类化合物最显著的结构特征，有利于其细胞毒性活性以及抑制乳酸释放的能力，似乎是2,3键的去饱和以及B环的连接位置。事实上，黄酮醇和黄酮是最有效的，并且在这两类中，效力顺序可由羟基或甲氧基取代基调节。另一方面，在我们的模型中，我们未发现黄酮类化合物结构与其调节cAMP水平能力之间存在任何相关性。最后一点将进行讨论。
