Kotch L E, Sulik K K
Department of Cell Biology and Anatomy, University of North Carolina School of Medicine, Chapel Hill.
Am J Med Genet. 1992 Sep 15;44(2):168-76. doi: 10.1002/ajmg.1320440210.
Acute teratogenic exposure of C57Bl/6J mouse embryos to ethanol in vivo results, within 12 hours of initial insult, in excessive cell death in selected cell populations. The patterns of excessive cell death observed following exposure of gestational day 8 embryos (late presomite--approximately 5 somite pair stages) vary somewhat temporospatially, but primarily involve the cell populations at the rim of the anterior neural plate. The cell death patterns appear to be pathogenically correlated with subsequently observed malformations including exencephaly (anencephaly), arhinencephaly, pituitary dysplasia, bilateral or unilateral cleft lip, maxillary hypoplasia, and median facial deficiencies and clefts. The association of these brain and facial malformations in this model, and perhaps in humans, may be accounted for by early insult to the selected cell populations identified in the current investigation.
在体内将C57Bl/6J小鼠胚胎急性致畸性暴露于乙醇，在初次损伤后的12小时内，会导致选定细胞群体中出现过度的细胞死亡。在妊娠第8天胚胎（晚期体节前期 - 大约5对体节阶段）暴露于乙醇后观察到的过度细胞死亡模式在时空上略有不同，但主要涉及前神经板边缘的细胞群体。细胞死亡模式似乎在发病机制上与随后观察到的畸形相关，包括无脑畸形（anencephaly）、无嗅脑畸形、垂体发育不全、双侧或单侧唇裂、上颌骨发育不全以及面部正中缺陷和腭裂。在该模型中，也许在人类中，这些脑和面部畸形的关联可能是由于对当前研究所确定的选定细胞群体的早期损伤所致。
