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与3',4'-四氢呋喃环稠合的嘧啶核苷的合成及生物学评价

Synthesis and biological evaluation of pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring.

作者信息

Chun Moon Woo, Kim Myong Jung, Kim Hea Ok, Moon Hyung Ryong, Kim Hee-Doo, Kim Joong Hyup, Jeong Lak Shin

机构信息

College of Pharmacy, Seoul National University, Seoul, Korea.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):719-21. doi: 10.1081/NCN-120022618.

DOI:10.1081/NCN-120022618
PMID:14565262
Abstract

Pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities. Thymine analogue 1 and its corresponding 2'-deoxy analogue 3 exhibited high cytotoxicity instead of giving antiviral activities.

摘要

从1,2;5,6-二-O-异亚丙基-D-葡萄糖开始合成了与3',4'-四氢呋喃环稠合的嘧啶核苷，并对其抗病毒活性进行了测定。胸腺嘧啶类似物1及其相应的2'-脱氧类似物3表现出高细胞毒性，而未表现出抗病毒活性。

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