Gelardi Matteo, Cassano Pasquale, Cassano Michele, Fiorella Maria Luisa
Department of Ophthalmology and Otolaryngology-Otolaryngology II, University School of Medicine, Bari, Italy.
Am J Rhinol. 2003 Sep-Oct;17(5):263-8.
The aim of this study was to describe a particular intracellular hyperchromatic formation located over the nucleus of normal nasal ciliated cells. This finding, never described in literature, very rarely occurs in pathological conditions.
A nasal cytological test and mucociliary transport test were performed in a group of 24 subjects with rhinologic diseases and in a control group of 10 healthy subjects.
The "hyperchromatic supranuclear stria" (SNS) was observed in a high percentage of normal cells (90.3%); SNS was present in very few pathological subjects (in only 6.26% of pathologic cells).
We interpreted SNS as a specific marker for the anatomic and functional integrity of the ciliated cell. Therefore, the absence of SNS is considered an abnormal finding in the nasal mucosa and therefore could be useful as a "prognostic sign" of the disorders themselves and as an indication of the "therapeutic efficacy" of pharmacologic treatments, both topical and systemic.
本研究的目的是描述一种位于正常鼻纤毛细胞核上方的特殊细胞内深染结构。这一从未在文献中描述过的发现，在病理状况下极少出现。
对24名患有鼻科疾病的受试者和10名健康受试者组成的对照组进行了鼻细胞学检查和黏液纤毛运输试验。
在高比例的正常细胞（90.3%）中观察到了“核上深染条纹”（SNS）；在极少数病理受试者中存在SNS（仅占病理细胞的6.26%）。
我们将SNS解释为纤毛细胞解剖和功能完整性的特异性标志物。因此，SNS的缺失被认为是鼻黏膜中的异常发现，故而可作为疾病本身的“预后指标”以及局部和全身药物治疗“疗效”的指标。
