Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Hum Exp Toxicol. 2010 May;29(5):427-9. doi: 10.1177/0960327109359640. Epub 2010 Jan 12.
A 27-year-old female nurse intravenously injected 5 mL of cigarette soakage solution that contained approximately 5.7 mg nicotine, in a suicidal attempt. Clinical manifestations consisted of nausea, palpitation, abdominal pain, repeated vomiting, and diarrhea. She remained fully conscious during this episode. About 7 hours later, she visited emergency department on foot and received fluid infusion for dehydration. She fully recovered at night of the day. This is the first documented report of acute nicotine poisoning due to intravenous injection of cigarette soakage in humans. Signs and symptoms appeared immediately after the injection, but this case seemed to be relatively mild in terms of clinical manifestation. The elimination half-life of nicotine seems to be short, that is, less than 1 hour. Therefore, if initial treatment is appropriate and the patient can survive acute phase of nicotine poisoning, prognosis is good.
一位 27 岁的女护士企图自杀，静脉注射了约 5 毫克尼古丁的 5 毫升烟浸液。临床表现为恶心、心悸、腹痛、反复呕吐和腹泻。在此期间，她保持完全清醒。大约 7 小时后，她步行到急诊科，接受了脱水治疗。她当天晚上完全康复了。这是首例有记录的人类因静脉注射烟浸液而导致急性尼古丁中毒的报告。注射后立即出现体征和症状，但就临床表现而言，该病例似乎相对较轻。尼古丁的消除半衰期似乎很短，即不到 1 小时。因此，如果初始治疗得当且患者能够存活过尼古丁中毒的急性期，预后良好。
