Sharma Anita, Bansal Satish, Nagpal R K
Department of Pediatrics, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Indian J Pediatr. 2003 Sep;70(9):715-7. doi: 10.1007/BF02724313.
To study the levels of free oxygen redicals in children with bronchial asthma during an attack and symptom free interval.
Serum Malondiadehyde (MDA) levels were studied in 25 children between the age of 6 years-14 years who presented with an acute attack of bronchial asthma. In each patient, serum MDA levels were measured at the time of admission, 24-48 hours after good response to treatment and after a symptom free interval of 3 weeks. Results were compared with control group.
In study group serum MDA levels were highest at the time of admission, which decreased significantly at 24-48 hours with treatment. After a 3 weeks symptom free interval serum MDA levels had decreased further but were still higher than healthy control group.
Lipid peroxidation is increased in bronchial asthma during an acute attack and symptom free period.
研究支气管哮喘患儿发作期及症状缓解期的游离氧自由基水平。
对25例6至14岁支气管哮喘急性发作患儿的血清丙二醛（MDA）水平进行研究。在每位患者入院时、治疗取得良好效果后24至48小时以及症状缓解3周后测量血清MDA水平。将结果与对照组进行比较。
研究组血清MDA水平在入院时最高，治疗后24至48小时显著下降。经过3周症状缓解期后，血清MDA水平进一步下降，但仍高于健康对照组。
支气管哮喘急性发作期及症状缓解期脂质过氧化增加。
