Cheeseman K H
Department of Biology and Biochemistry, Brunel University, Uxbridge, U.K.
Mol Aspects Med. 1993;14(3):191-7. doi: 10.1016/0098-2997(93)90005-x.
Lipid peroxidation is an important mechanism in free radical mediated cell injury. It can damage cell membranes directly and the reactive carbonyl products may spread the damage far from the original site of radical production. It has long been considered to be involved in various toxic tissue injuries and in certain disease processes, including cancer. Paradoxically, cancer cells are very resistant to lipid peroxidation. Recently, it has been suggested that lipid peroxidation may exert more subtle effects than was previously thought possible, by influencing gene expression.
脂质过氧化是自由基介导的细胞损伤中的一个重要机制。它可直接损伤细胞膜，并且反应性羰基产物可能将损伤扩散至远离自由基产生的原始部位。长期以来，人们一直认为它参与各种毒性组织损伤以及某些疾病过程，包括癌症。矛盾的是，癌细胞对脂质过氧化具有很强的抗性。最近，有人提出脂质过氧化可能通过影响基因表达发挥比之前认为的更微妙的作用。
