Kasorndorkbua Chaiyan, Thacker Brad J, Halbur Patrick G, Guenette Denis K, Buitenwerf Ryan M, Royer Ryan L, Meng Xiang-Jin
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.
Can J Vet Res. 2003 Oct;67(4):303-6.
To determine the effect of swine hepatitis E virus (HEV) infection on pregnant gilts, their fetuses, and offspring, 12 gilts were intravenously inoculated with swine HEV. Six gilts, who were not inoculated, served as controls. All inoculated gilts became actively infected and shed HEV in feces, but vertical transmission was not detected in the fetuses. There was no evidence of clinical disease in the gilts or their offspring. Mild multifocal lymphohistiocytic hepatitis was observed in 4 of 12 inoculated gilts. There was no significant effect of swine HEV on fetal size, fetal viability, or offspring birth weight or weight gain. The offspring acquired anti-HEV colostral antibodies but remained seronegative after the antibodies waned by 71 days of age. Swine HEV infection induced subclinical hepatitis in pregnant gilts, but had no effect on the gilts' reproductive performance, or the fetuses or offspring. Fulminant hepatitis associated with HEV infection was not reproduced in gilts.
为确定猪戊型肝炎病毒（HEV）感染对妊娠后备母猪、其胎儿及后代的影响，对12头后备母猪进行了猪HEV静脉接种。6头未接种的后备母猪作为对照。所有接种的后备母猪均发生主动感染并通过粪便排出HEV，但未在胎儿中检测到垂直传播。在后备母猪及其后代中未发现临床疾病迹象。在12头接种的后备母猪中有4头观察到轻度多灶性淋巴细胞性肝炎。猪HEV对胎儿大小、胎儿活力或后代出生体重及体重增加无显著影响。后代获得了抗HEV初乳抗体，但在抗体在71日龄时消退后仍保持血清学阴性。猪HEV感染在妊娠后备母猪中诱发亚临床肝炎，但对后备母猪的繁殖性能、胎儿或后代无影响。在后备母猪中未再现与HEV感染相关的暴发性肝炎。
