Dumortier M, Brandou F, Perez-Martin A, Fedou C, Mercier J, Brun J F
Service Central de Physiologie Clinique, Centre d'Exploration et de Réadaptation des Anomalies du Métabolisme Musculaire, CHU Lapeyronie, Montpellier, France.
Diabetes Metab. 2003 Nov;29(5):509-18. doi: 10.1016/s1262-3636(07)70065-4.
To investigate the effects of individualized training on the metabolic syndrome.
Twenty-eight patients, suffering from the metabolic syndrome were studied before and after 2 months of training and compared to eleven patients who did not follow any training. All the patients were overweight. Training was individualized at the point where fat oxidation was maximal (LIPOX(max)) as determined by calorimetry.
The patients exhibited a significant reduction in body weight (- 2.6 +/- 0.7 kg; P=0.002), fat mass (- 1.55 +/- 0.5 kg; P=0.009), waist (- 3.53 +/- 1.3 cm; P<0.05) and hip (- 2.21 +/- 0.9 cm; P<0.05) circumferences, and improved the ability to oxidize lipids at exercise (crossover point: + 31.7 +/- 5.8 W; P<0.0001; LIPOX(max): + 23.5 +/- 5.6 W; P<0.0001; lipid oxidation: + 68.5 +/- 15.4 mg.min(-1); P=0.0001). No clear improvement in either lipid parameters or fibrinogen were observed. The surrogates of insulin sensitivity evidenced a decrease in insulin resistance: HOMA%S (software): + 72.93 +/- 32.64; p<0.05; HOMA-IR (simplified formula): - 2.42 +/- 1.07; P<0.05; QUICKI: + 0.02 +/- 0.004; P<0.01; SI=40/I: + 3.28 +/- 1.5; P<0.05. Significant correlations were found between changes in body weight and HOMA-IR and between changes in LIPOX(max) and QUICKI.
Individualized aerobic training improves lipid oxidation, body composition and insulin resistance.
研究个性化训练对代谢综合征的影响。
对28例患有代谢综合征的患者在训练2个月前后进行研究，并与11例未进行任何训练的患者进行比较。所有患者均超重。训练根据热量测定法确定的脂肪氧化最大值（LIPOX(max)）进行个性化定制。
患者体重显著减轻（-2.6±0.7 kg；P = 0.002）、脂肪量减少（-1.55±0.5 kg；P = 0.009）、腰围减小（-3.53±1.3 cm；P < 0.05）、臀围减小（-2.21±0.9 cm；P < 0.05），运动时脂质氧化能力提高（交叉点：+31.7±5.8 W；P < 0.0001；LIPOX(max)：+23.5±5.6 W；P < 0.0001；脂质氧化：+68.5±15.4 mg·min⁻¹；P = 0.0001）。未观察到脂质参数或纤维蛋白原的明显改善。胰岛素敏感性指标显示胰岛素抵抗降低：HOMA%S（软件）：+72.93±32.64；p < 0.05；HOMA-IR（简化公式）：-2.42±1.07；P < 0.05；QUICKI：+0.02±0.004；P < 0.01；SI = 40/I：+3.28±1.5；P < 0.05。体重变化与HOMA-IR之间以及LIPOX(max)变化与QUICKI之间存在显著相关性。
个性化有氧训练可改善脂质氧化、身体成分和胰岛素抵抗。
