Lönn Stefan, Klaeboe Lars, Hall Per, Mathiesen Tiit, Auvinen Anssi, Christensen Helle C, Johansen Christoffer, Salminen Tiina, Tynes Tore, Feychting Maria
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Int J Cancer. 2004 Jan 20;108(3):450-5. doi: 10.1002/ijc.11578.
Brain tumors are some of the most lethal adult cancers and there is a concern that the incidence is increasing. It has been suggested that the reported increased incidence can be explained by improvements in diagnostic procedures, although this has not been totally resolved. The aim of our study was to describe the incidence trends of adult primary intracerebral tumors in four Nordic countries during a period with introduction of new diagnostic procedures and increasing prevalence of mobile phone users. Information about benign and malignant primary intracerebral tumor cases 20-79 years of age was obtained from the national cancer registries in Denmark, Finland, Norway and Sweden for the years 1969-98 and estimates of person-years at risk were calculated from the information obtained from national population registries. Annual age standardized incidence rates per 100,000 person-years were calculated and time trends analyses were carried out using Poisson regression. The overall incidence of all intracerebral tumors ranged from 8.4-11.8 for men and 5.8-9.3 for women, corresponding to an average annual increase of 0.6% for men (95% confidence interval [CI] = 0.4, 0.7) and 0.9% for women (95% CI = 0.7, 1.0). The increase in the incidence was confined to the late 1970s and early 1980s and coinciding with introduction of improved diagnostic methods. This increase was largely confined to the oldest age group. After 1983 and during the period with increasing prevalence of mobile phone users, the incidence has remained relatively stable for both men and women.
脑肿瘤是最致命的成人癌症之一，人们担心其发病率正在上升。有人认为，报告的发病率上升可以用诊断程序的改进来解释，尽管这一问题尚未完全解决。我们研究的目的是描述在引入新诊断程序和手机用户普及率不断上升的时期，四个北欧国家成人原发性脑肿瘤的发病率趋势。从丹麦、芬兰、挪威和瑞典的国家癌症登记处获取了1969年至1998年20至79岁的原发性脑良性和恶性肿瘤病例信息，并根据从国家人口登记处获得的信息计算了风险人年数。计算了每10万人年的年龄标准化发病率，并使用泊松回归进行了时间趋势分析。所有脑肿瘤的总体发病率男性为8.4至11.8，女性为5.8至9.3，男性平均每年增加0.6%（95%置信区间[CI]=0.4，0.7），女性为0.9%（95%CI=0.7，1.0）。发病率的增加仅限于20世纪70年代末和80年代初，与改进的诊断方法的引入同时发生。这种增加主要局限于最年长的年龄组。1983年以后，在手机用户普及率不断上升的时期，男性和女性的发病率都保持相对稳定。
