来自植物乳杆菌MiLAB 14的抗真菌3-羟基脂肪酸
Antifungal 3-hydroxy fatty acids from Lactobacillus plantarum MiLAB 14.
作者信息
Sjögren Jörgen, Magnusson Jesper, Broberg Anders, Schnürer Johan, Kenne Lennart
机构信息
Department of Chemistry, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
出版信息
Appl Environ Microbiol. 2003 Dec;69(12):7554-7. doi: 10.1128/AEM.69.12.7554-7557.2003.
Abstract
We report the identification and chemical characterization of four antifungal substances, 3-(R)-hydroxydecanoic acid, 3-hydroxy-5-cis-dodecenoic acid, 3-(R)-hydroxydodecanoic acid and 3-(R)-hydroxytetradecanoic acid, from Lactobacillus plantarum MiLAB 14. The concentrations of the 3-hydroxy fatty acids in the supernatant followed the bacterial growth. Racemic mixtures of the saturated 3-hydroxy fatty acids showed antifungal activity against different molds and yeasts with MICs between 10 and 100 micrograms ml-1.
摘要
我们报告了从植物乳杆菌MiLAB 14中鉴定出四种抗真菌物质及其化学特性，它们分别是3-(R)-羟基癸酸、3-羟基-5-顺-十二碳烯酸、3-(R)-羟基十二烷酸和3-(R)-羟基十四烷酸。上清液中3-羟基脂肪酸的浓度随细菌生长而变化。饱和3-羟基脂肪酸的外消旋混合物对不同的霉菌和酵母菌显示出抗真菌活性，其最低抑菌浓度在10至100微克/毫升之间。
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