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希腊重症监护病房中耐糖肽屎肠球菌出现期间肠球菌表面蛋白基因（esp）的检测及耐糖肽屎肠球菌的扩增片段长度多态性分型

Detection of enterococcal surface protein gene (esp) and amplified fragment length polymorphism typing of glycopeptide-resistant Enterococcus faecium during its emergence in a Greek intensive care unit.

作者信息

Routsi C, Platsouka E, Willems R J L, Bonten M J M, Paniara O, Saroglou G, Roussos C

机构信息

Department of Critical Care, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.

出版信息

J Clin Microbiol. 2003 Dec;41(12):5742-6. doi: 10.1128/JCM.41.12.5742-5746.2003.

DOI:10.1128/JCM.41.12.5742-5746.2003
PMID:14662973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC308986/
Abstract

The emergence of glycopeptide-resistant Enterococcus faecium (GREF) in a Greek intensive care unit was studied by amplified fragment length polymorphism analysis and esp gene detection. Three GREF clones harboring the esp gene were recovered from 17 out of 21 patients, indicating the dissemination of genetically homogenous and virulent strains of GREF.

摘要

通过扩增片段长度多态性分析和esp基因检测，对希腊一家重症监护病房中耐糖肽粪肠球菌（GREF）的出现情况进行了研究。从21名患者中的17名患者身上分离出了三个携带esp基因的GREF克隆，这表明基因同源且具有毒性的GREF菌株正在传播。

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本文引用的文献

1
High occurrence of esp among ampicillin-resistant and vancomycin-susceptible Enterococcus faecium clones from hospitalized patients.来自住院患者的耐氨苄西林且对万古霉素敏感的屎肠球菌克隆中，肠球菌表面蛋白（esp）的高发生率。
J Antimicrob Chemother. 2002 Dec;50(6):1035-8. doi: 10.1093/jac/dkf229.
2
Association between the presence of enterococcal virulence factors gelatinase, hemolysin, and enterococcal surface protein and mortality among patients with bacteremia due to Enterococcus faecalis.粪肠球菌引起的菌血症患者中，肠球菌毒力因子明胶酶、溶血素和肠球菌表面蛋白的存在与死亡率之间的关联。
Clin Infect Dis. 2002 Sep 1;35(5):570-5. doi: 10.1086/341977. Epub 2002 Aug 2.
3
Vancomycin-resistant enterococci: why are they here, and where do they come from?耐万古霉素肠球菌：它们为何存在于此，又源自何处？
Lancet Infect Dis. 2001 Dec;1(5):314-25. doi: 10.1016/S1473-3099(01)00145-1.
4
Variant esp gene as a marker of a distinct genetic lineage of vancomycin-resistant Enterococcus faecium spreading in hospitals.变异的esp基因作为医院中传播的耐万古霉素屎肠球菌一个独特遗传谱系的标志物。
Lancet. 2001 Mar 17;357(9259):853-5. doi: 10.1016/S0140-6736(00)04205-7.
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The first clinical isolates of Enterococcus faecium with the VanA phenotype in a tertiary Greek hospital.希腊一家三级医院中首次分离出具有VanA表型的屎肠球菌临床菌株。
J Antimicrob Chemother. 2000 Dec;46(6):1039-40. doi: 10.1093/jac/46.6.1039.
6
Evaluation of fluorescence-based amplified fragment length polymorphism analysis for molecular typing in hospital epidemiology: comparison with pulsed-field gel electrophoresis for typing strains of vancomycin-resistant Enterococcus faecium.基于荧光的扩增片段长度多态性分析在医院流行病学分子分型中的评估：与脉冲场凝胶电泳用于耐万古霉素屎肠球菌菌株分型的比较
J Clin Microbiol. 2000 Nov;38(11):4058-65. doi: 10.1128/JCM.38.11.4058-4065.2000.
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J Infect Dis. 2000 Sep;182(3):816-23. doi: 10.1086/315752. Epub 2000 Aug 10.
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Enterococcal infections in a Greek intensive care unit: a 5-y study.希腊一家重症监护病房的肠球菌感染：一项为期5年的研究。
Scand J Infect Dis. 2000;32(3):275-80. doi: 10.1080/00365540050165910.
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National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1990-May 1999, issued June 1999. A report from the NNIS System.国家医院感染监测（NNIS）系统报告，1990年1月至1999年5月数据总结，1999年6月发布。NNIS系统报告。
Am J Infect Control. 1999 Dec;27(6):520-32. doi: 10.1016/s0196-6553(99)70031-3.
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Antimicrobial susceptibility patterns of enterococci causing infections in Europe. The European VRE Study Group.欧洲引起感染的肠球菌的抗菌药敏模式。欧洲耐万古霉素肠球菌研究小组。
Antimicrob Agents Chemother. 1999 Oct;43(10):2542-6. doi: 10.1128/AAC.43.10.2542.