Mallon Eamonn B, Brockmann Axel, Schmid-Hempel Paul
Ecology and Evolution, ETH Zürich, ETH-Zentrum NW, CH-8092 Zürich, Switzerland.
Proc Biol Sci. 2003 Dec 7;270(1532):2471-3. doi: 10.1098/rspb.2003.2456.
In vertebrates, it is well established that there are many intricate interactions between the immune system and the nervous system, and vice versa. Regarding insects, until now little has been known about the link between these two systems. Here, we present behavioural evidence indicating a link between the immune system and the nervous system in insects. We show that otherwise non-infected honeybees whose immune systems are challenged by a non-pathogenic immunogenic elicitor lipopolysaccharide (LPS) have reduced abilities to associate an odour with sugar reward in a classical conditioning paradigm. The cost of an immune response therefore not only affects survival of the host, as previously shown, but also everyday behaviour and memory formation.
在脊椎动物中，免疫系统与神经系统之间存在许多复杂的相互作用，反之亦然，这一点已得到充分证实。至于昆虫，到目前为止，人们对这两个系统之间的联系知之甚少。在此，我们提供行为学证据，表明昆虫的免疫系统与神经系统之间存在联系。我们发现，在经典条件反射范式中，原本未受感染但免疫系统受到非致病性免疫原性激发物脂多糖（LPS）挑战的蜜蜂，将气味与糖奖励联系起来的能力有所下降。因此，免疫反应的代价不仅如先前所示影响宿主的生存，还会影响日常行为和记忆形成。
