Shiba T, Mitooka K, Tsuneoka H
Department of Ophthalmology, Jikei University, School of Medicine, Tokyo, Japan.
Eur J Ophthalmol. 2003 Nov-Dec;13(9-10):759-63. doi: 10.1177/1120672103013009-1004.
The authors studied the effects of changes in packaging solution temperature on the development of glistening in acrylic intraocular lenses (AcrySof, Alcon).
Glistening was examined by slit lamp at each condition. In Experiment 1, AcrySof lenses were soaked in physiologic saline adjusted to 15 degrees C and 37 degrees C in an incubator. In Experiment 2, AcrySof lenses were soaked in physiologic saline adjusted to 37 degrees C and 60 degrees C for 5 min, then stored in physiologic saline adjusted to 15 degrees C. In Experiment 3, glistening formation was induced in AcrySof lenses by soaking them in warm water (37 degrees C). The lenses were allowed to dry at 15 degrees C and then soaked in physiologic saline adjusted to 15 degrees C. After storage of dry AcrySof lenses at 37 degrees C in an incubator for 10 months followed by soaking in physiologic saline adjusted to 15 degrees C, glistening formation was evaluated in Experiment 4.
Glistening became observable after 1 month, despite the temperature having been lowered to 15 degrees C. No glistening was observed in the lenses soaked in physiologic saline adjusted to 37 degrees C after 5 min, but glistening was observed 1 month after soaking. When allowed to dry at 15 degrees C, the glistening decreased. After 1 month of soaking at 15 degrees C, glistening was again observable.
AcrySof lenses soaked in warm water for a short time may change characteristics, and therefore, close monitoring of the temperature and time of soaking is necessary to prevent glistening formation.
作者研究了包装溶液温度变化对丙烯酸人工晶状体（爱尔康公司的AcrySof）表面出现闪光点的影响。
在每种条件下通过裂隙灯检查闪光点情况。实验1中，将AcrySof晶状体在培养箱中浸泡于温度调节为15℃和37℃的生理盐水中。实验2中，将AcrySof晶状体浸泡于温度调节为37℃和60℃的生理盐水中5分钟，然后储存在温度调节为15℃的生理盐水中。实验3中，通过将AcrySof晶状体浸泡于温水（37℃）诱导闪光点形成。让晶状体在15℃下干燥，然后浸泡于温度调节为15℃的生理盐水中。在培养箱中于37℃储存干燥的AcrySof晶状体10个月，之后浸泡于温度调节为15℃的生理盐水中，在实验4中评估闪光点形成情况。
尽管温度已降至15℃，但1个月后闪光点变得可见。在温度调节为37℃的生理盐水中浸泡5分钟后，晶状体未观察到闪光点，但浸泡1个月后观察到了闪光点。当在15℃下干燥时，闪光点减少。在15℃下浸泡1个月后，闪光点再次可见。
短时间浸泡于温水中的AcrySof晶状体可能会改变特性，因此，为防止闪光点形成，必须密切监测浸泡温度和时间。
