AlMoharib Hani S, AlMubarak Abdulrahman, AlRowis Raed, Geevarghese Amrita, Preethanath R S, Anil Sukumaran
Teaching Assistant, Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Lecturer, Department of Dental Public Health, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.
J Int Oral Health. 2014 Jul;6(4):95-103.
Traditional clinical measurements such as probing pocket depth, bleeding on probing, clinical attachment loss; plaque index and radiographs used for periodontal diagnosis are often of limited usefulness as they are indicators of previous periodontal disease rather than present disease activity. A literature search was carried out to find out all the available tests that indicate periodontal disease markers in saliva. All major databases were searched to compile the information on published reports between 1999 and 2014. The list of biomarkers available to date is compiled and presented in a table format. Each biomarker is discussed separately based on the available evidence. Based on the evidence, it can be concluded that several sensitive salivary indicators of periodontitis are available to detect the presence, severity and response to treatment. Further studies are warranted to analyze the sensitivity and reliability of these indicators that might help in developing non-invasive tests that could help in the diagnosis of periodontal disease.
传统的临床测量方法，如牙周袋探诊深度、探诊出血、临床附着丧失；菌斑指数以及用于牙周诊断的X光片，其用途往往有限，因为它们是既往牙周疾病的指标，而非当前疾病活动的指标。进行了一项文献检索，以找出所有可用于指示唾液中牙周疾病标志物的现有测试。检索了所有主要数据库，以汇总1999年至2014年间发表报告的相关信息。将迄今为止可用的生物标志物列表进行汇编，并以表格形式呈现。根据现有证据对每种生物标志物进行单独讨论。基于这些证据，可以得出结论，有几种敏感的唾液牙周炎指标可用于检测牙周炎的存在、严重程度以及对治疗的反应。有必要进一步开展研究，分析这些指标的敏感性和可靠性，这可能有助于开发有助于牙周疾病诊断的非侵入性测试。
