Hinsberger A D, Williamson P C, Carr T J, Stanley J A, Drost D J, Densmore M, MacFabe G C, Montemurro D G
Department of Psychiatry, University of Western Ontario, London, Canada.
J Psychiatry Neurosci. 1997 Mar;22(2):111-7.
The purpose of this study was to examine the relationship between phosphorus magnetic resonance spectroscopy (31P MRS) parameters and left prefrontal volumes in both patients with schizophrenia and healthy subjects. 31P MRS parameters and magnetic resonance imaging (MRI) volumetric data were collected in the left prefrontal region in 10 patients with schizophrenia and 10 healthy subjects of comparable age, handedness, sex, educational level, and parental educational level. No correlations were found between any MRS parameter and grey matter volumes in the combined subjects. Phosphomonoester (PME) and grey matter volumes, however, were both correlated negatively with age. PMEs were found to be decreased, and calculated intracellular magnesium ([Mg2+]intra) was found to be increased in the patients with schizophrenia compared with healthy subjects after adjusting for left prefrontal grey and white matter, total brain volume, and age. These findings suggest that cortical grey and white manner volumes are not directly related to PME and [Mg2+]intra abnormalities in schizophrenia patients.
本研究的目的是在精神分裂症患者和健康受试者中，检验磷磁共振波谱（31P MRS）参数与左前额叶体积之间的关系。收集了10例精神分裂症患者和10例年龄、利手、性别、教育水平及父母教育水平相匹配的健康受试者左前额叶区域的31P MRS参数和磁共振成像（MRI）体积数据。在合并的受试者中，未发现任何MRS参数与灰质体积之间存在相关性。然而，磷酸单酯（PME）和灰质体积均与年龄呈负相关。在对左前额叶灰质和白质、全脑体积及年龄进行校正后，发现精神分裂症患者的PME降低，而计算得出的细胞内镁（[Mg2+]intra）升高。这些发现表明，皮质灰质和白质体积与精神分裂症患者的PME及[Mg2+]intra异常并无直接关系。
