Liu Xuan, Shi Yulin, Li Ping, Li Linhai, Yi Yanping, Ma Qingjun, Cao Cheng
Beijing Institute of Biotechnology, Beijing 100850, Peoples Republic of China.
Clin Diagn Lab Immunol. 2004 Jan;11(1):227-8. doi: 10.1128/cdli.11.1.227-228.2004.
Profiles of antibodies to the nucleocapsid protein of the severe acute respiratory syndrome (SARS)-associated coronavirus in 445 probable SARS patients and 3,749 healthy people or non-SARS patients were analyzed by antigen-capturing enzyme-linked immunosorbent assay. Antinucleocapsid antibodies were elucidated in 17.5% of the probable SARS patients 1 to 7 days after the onset of symptoms and in 80% of the patients 8 to 14 days after the onset. About 90% of the probable SARS patients were positive 15 or more days after illness. Antibody titers increased up to 70 days, and high antibody titers were maintained at least for another 3 months. Of the healthy people and non-SARS patients, only seven (0.187%) were weakly positive.
采用抗原捕获酶联免疫吸附试验分析了445例疑似严重急性呼吸综合征（SARS）患者以及3749例健康人或非SARS患者针对SARS相关冠状病毒核衣壳蛋白的抗体谱。17.5%的疑似SARS患者在症状出现后1至7天可检测到抗核衣壳抗体，80%的患者在症状出现后8至14天可检测到。约90%的疑似SARS患者在发病15天及以上呈阳性。抗体滴度在70天内升高，高抗体滴度至少维持3个月。在健康人和非SARS患者中，只有7人（0.187%）呈弱阳性。
