Carson Katherine R, Goodell Gary G, McClanahan Scott B
Naval Postgraduate Dental School, Bethesda, MD, USA.
J Endod. 2005 Jun;31(6):471-3. doi: 10.1097/01.don.0000148868.72833.62.
The purpose of this study was to compare the antimicrobial activities of 6% and 3% sodium hypochlorite (NaOCl), 2% and 0.12% chlorhexidine gluconate (CHX), and 0.01% and 0.005% doxycycline (Doxy) on four microorganisms associated with primary endodontic infections. The agar diffusion test was used to measure antimicrobial activities of these agents against Peptostreptococcus micros, Prevotella intermedia, Streptococcus sanguis, and Lactobacillus acidophilus. Minimum inhibitory concentration analysis was performed using the macrodilution method. For three of the four microorganisms, the general order of antimicrobial effectiveness was 0.01% Doxy >0.005% Doxy >6% NaOCl >3% NaOCl >2% CHX > 0.12% CHX. For L. acidophilus, the order of effectiveness was 6% NaOCl >3% NaOCl >2% CHX > 0.01% Doxy >0.005% Doxy >0.12% CHX. The 6% NaOCl showed significantly greater zones of inhibition than 3% NaOCl for all endopathogens tested.
本研究的目的是比较6%和3%的次氯酸钠（NaOCl）、2%和0.12%的葡萄糖酸氯己定（CHX）以及0.01%和0.005%的多西环素（强力霉素）对四种与原发性牙髓感染相关的微生物的抗菌活性。采用琼脂扩散试验来测定这些药物对微小消化链球菌、中间普雷沃菌、血链球菌和嗜酸乳杆菌的抗菌活性。使用常量稀释法进行最低抑菌浓度分析。对于四种微生物中的三种，抗菌效力的一般顺序为0.01%强力霉素>0.005%强力霉素>6%次氯酸钠>3%次氯酸钠>2%葡萄糖酸氯己定>0.12%葡萄糖酸氯己定。对于嗜酸乳杆菌，效力顺序为6%次氯酸钠>3%次氯酸钠>2%葡萄糖酸氯己定>0.01%强力霉素>0.005%强力霉素>0.12%葡萄糖酸氯己定。对于所有测试的牙髓病原菌，6%的次氯酸钠显示出比3%次氯酸钠明显更大的抑菌圈。
