Lillebaek Troels, Andersen Ase B, Dirksen Asger, Glynn Judith R, Kremer Kristin
National Institute for Prevention and Control of Infectious Diseases and Congenital Disorders, Copenhagen, Denmark.
Emerg Infect Dis. 2003 Dec;9(12):1553-7. doi: 10.3201/eid0912.030276.
Molecular epidemiologic studies of strains of Mycobacterium tuberculosis are currently conducted worldwide. The genetically distinct Beijing family of strains has been associated with large outbreaks of tuberculosis, increased virulence, and multidrug resistance. However, in this first population-based search for Beijing strains in the Danish DNA fingerprint database, analysis of 97% of all culture-positive tuberculosis patients in 1992 to 2001 showed that 2.5% of 3,844 patients, 1.0% of Danish-born patients, and 3.6% of immigrants (from 85 countries) had Beijing strains. No Beijing strains were found among 201 strains from Danish-born patients sampled in the 1960s, and no evidence of an increase in Beijing strains was found over time. The true prevalence of Beijing strains worldwide is unknown because only a fraction of global strains have been analyzed.
目前全球都在开展结核分枝杆菌菌株的分子流行病学研究。具有独特遗传特征的北京家族菌株与大规模结核病暴发、毒力增强以及多重耐药性有关。然而，在丹麦DNA指纹数据库中首次基于人群搜索北京菌株时，对1992年至2001年所有培养阳性结核病患者的97%进行分析发现，3844例患者中有2.5%、丹麦出生患者中有1.0%以及移民（来自85个国家）中有3.6%携带北京菌株。在20世纪60年代采集的201株丹麦出生患者菌株中未发现北京菌株，且未发现北京菌株随时间增加的迹象。由于仅分析了全球菌株的一小部分，因此北京菌株在全球的真实流行率尚不清楚。
