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全碳季碳立体中心的催化不对称合成。

Catalytic asymmetric synthesis of all-carbon quaternary stereocenters.

作者信息

Douglas Christopher J, Overman Larry E

机构信息

Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.

出版信息

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5363-7. doi: 10.1073/pnas.0307113101. Epub 2004 Jan 14.

DOI:10.1073/pnas.0307113101
PMID:14724294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC397386/
Abstract

Only a few catalytic asymmetric C-C bond-forming reactions have been shown to be useful for constructing all-carbon quaternary stereocenters. This Perspective examines the current state of such methods.

摘要

仅有少数催化不对称C-C键形成反应被证明可用于构建全碳季碳立体中心。本文综述了此类方法的现状。

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2
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3
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4
Asymmetric Phase-Transfer Catalysis.
Angew Chem Int Ed Engl. 1999 Jun 1;38(11):1583-1585. doi: 10.1002/(SICI)1521-3773(19990601)38:11<1583::AID-ANIE1583>3.0.CO;2-E.
5
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Angew Chem Int Ed Engl. 2002 May 17;41(10):1650-67. doi: 10.1002/1521-3773(20020517)41:10<1650::aid-anie1650>3.0.co;2-b.
6
Enantioselective Michael additions to alpha,beta-unsaturated imides catalyzed by a Salen-Al complex.
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7
Development of chiral nucleophilic pyridine catalysts: applications in asymmetric quaternary carbon synthesis.手性亲核吡啶催化剂的开发:在不对称季碳合成中的应用。
J Am Chem Soc. 2003 Nov 5;125(44):13368-9. doi: 10.1021/ja037223k.
8
Catalytic enantioselective synthesis of oxindoles and benzofuranones that bear a quaternary stereocenter.
Angew Chem Int Ed Engl. 2003 Aug 25;42(33):3921-4. doi: 10.1002/anie.200351666.
9
Enantioselective rare-earth catalyzed quinone Diels-Alder reactions.
J Am Chem Soc. 2003 Aug 27;125(34):10162-3. doi: 10.1021/ja0367602.
10
Nucleophilic chiral amines as catalysts in asymmetric synthesis.
Chem Rev. 2003 Aug;103(8):2985-3012. doi: 10.1021/cr020061a.